abstract：BACKGROUND:In this study, the authors studied the effect of thioridazine (TDZ) on the pharmacokinetic profile of quetiapine (QTP) in Taiwanese patients with schizophrenia. METHODS:Sixteen subjects with schizophrenia were recruited for this study. The authors pretreated 8 patients with TDZ 50 mg daily continuously give...

journal_title：Therapeutic drug monitoring

authors： Chang SC,Lu ML,Wang YC,Lin FW,Huang SH,Kuo PH,Ho HO,Wu TH

更新日期：2012-06-01 00:00:00

abstract：:This case report highlights a very rare adverse drug reaction caused by oral aripiprazole resulting in severe hypoglycemia. A 72-year-old-male patient suffering from Parkinson disease on prolonged carbidopa plus levodopa combination therapy (carbidopa 25 mg plus levodopa 100 mg, thrice daily) for 1.3 years was recentl...

journal_title：Therapeutic drug monitoring

authors： Mondal S,Saha I,Das S,Ganguly A,Ghosh A,Kumar Das A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Beta-lactams are first-line antibiotics for the management of superficial infections due to burn injury. There is sparse data available on therapeutic drug monitoring (TDM) in patients with burns in a ward setting. This study was conducted to evaluate the utility of a beta-lactam TDM program in a cohort of b...

journal_title：Therapeutic drug monitoring

authors： Patel BM,Paratz J,See NC,Muller MJ,Rudd M,Paterson D,Briscoe SE,Ungerer J,McWhinney BC,Lipman J,Roberts JA

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV)-infected individuals show large interindividual variation in response to antiretroviral therapy. Efavirenz (EFV) and nevirapine (NVP) are nonnucleoside reverse transcriptase inhibitors, which are prescribed in combination with other antiretroviral therapy in so-called highl...

journal_title：Therapeutic drug monitoring

authors： Heil SG,van der Ende ME,Schenk PW,van der Heiden I,Lindemans J,Burger D,van Schaik RH

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Antiepileptic drug therapeutic regimens often need to be adjusted individually on the basis of serum assays. We aimed to develop a quantitative, fast, and sensitive liquid chromatography-tandem mass spectrometry method to simultaneously analyze carbamazepine, oxcarbazepine, and the 10-11 epoxide carbamazepin...

journal_title：Therapeutic drug monitoring

authors： Lionetto L,Casolla B,Cavallari M,Tisei P,Buttinelli C,Simmaco M

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Body weight may affect pharmacokinetic parameters in various ways and may therefore have a significant impact on the serum concentration of a drug at a given dose. Although patients with major depressive disorder frequently show an elevated body mass index, studies investigating the relation between body wei...

journal_title：Therapeutic drug monitoring

authors： Unterecker S,Deckert J,Pfuhlmann B

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Buprenorphine is currently under investigation as a pharmacotherapy to treat pregnant women for opioid dependence. This research evaluates buprenorphine (BUP), norbuprenophine (NBUP), buprenorphine-glucuronide (BUP-Gluc), and norbuprenorphine-glucuronide (NBUP-Gluc) pharmacokinetics after high-dose (14-20 mg...

journal_title：Therapeutic drug monitoring

authors： Concheiro M,Jones HE,Johnson RE,Choo R,Huestis MA

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The efficacy of drugs for the treatment of substance-related disorders is moderate at best. Therapeutic drug monitoring (TDM) could be an instrument to improve outcomes. Because TDM for most of those drugs is not established, the authors reviewed the literature and built a rating scale to detect the potentia...

journal_title：Therapeutic drug monitoring

authors： Brünen S,Vincent PD,Baumann P,Hiemke C,Havemann-Reinecke U

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Infliximab is a chimeric monoclonal antibody that binds to human tumor necrosis factor alpha and which is approved for refractory spondyloarthritis (SpA). Individual adjustment of infliximab dosage may help to improve the therapeutic response in SpA. We investigated whether a knowledge of infliximab serum co...

journal_title：Therapeutic drug monitoring

authors： Méric JC,Mulleman D,Ducourau E,Lauféron F,Miow Lin DC,Watier H,Goupille P,Paintaud G

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Posaconazole is an azole antifungal agent with a broad spectrum of activity and a manageable side-effect profile. Although the pharmacokinetics of posaconazole have been described in healthy volunteers who received the drug by means of a nasogastric tube or with nutritional supplements, the pharmacokinetics ...

journal_title：Therapeutic drug monitoring

authors： Ray J,Campbell L,Rudham S,Nguyen Q,Marriott D

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:We report a feasibility study based on our large-scale experience with mycophenolate mofetil dose adjustment based on mycophenolic acid interdose area under the curve (AUC) in renal transplant patients. METHODS:Between 2005 and 2010, 13,930 requests for 7090 different patients (outside any clinical trial) w...

journal_title：Therapeutic drug monitoring

authors： Saint-Marcoux F,Vandierdonck S,Prémaud A,Debord J,Rousseau A,Marquet P

更新日期：2011-06-01 00:00:00

abstract：:This study explored the association of 14 single nucleotide polymorphisms in three genes coding for influx transporters (SLC22A1, SLCO1B1, and SLCO1B3), two genes coding for efflux transporters (ABCB1 and ABCG2), and four genes coding for enzymes (CYP2C9, CYP2C19, CYP2D6, and CYP3A5) with the pharmacokinetics of imati...

journal_title：Therapeutic drug monitoring

authors： Yamakawa Y,Hamada A,Nakashima R,Yuki M,Hirayama C,Kawaguchi T,Saito H

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Gabapentin (Neurontin) and levetiracetam (Keppra) are anticonvulsants with novel structures and suggested therapeutic ranges of 2-10 mg/L and 6-20 mg/L, respectively. Gabapentin is also used extensively to manage neuropathic pain, and for this indication, wherein higher doses are prescribed, plasma concent...

journal_title：Therapeutic drug monitoring

authors： Juenke JM,Brown PI,Johnson-Davis KL,McMillin GA

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The association of CYP3A5, CYP3A4, and ABCB1 single nucleotide polymorphisms (SNPs) with cyclosporine (CsA) pharmacokinetics is controversial. The authors studied the influence of these SNPs on CsA pharmacokinetics as well as on the incidence of biopsy-proven acute rejection (BPAR) and renal function after k...

journal_title：Therapeutic drug monitoring

authors： Bouamar R,Hesselink DA,van Schaik RH,Weimar W,Macphee IA,de Fijter JW,van Gelder T

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to d...

journal_title：Therapeutic drug monitoring

authors： Kiberd BA,Wrobel M,Dandavino R,Keown P,Gourishankar S

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:The anticonvulsant properties of phenytoin (PHT) were discovered in 1938. Since then, it has been one of the most widely used antiepileptic drugs. It is slowly absorbed, extensively plasma protein-bound, exhibits a nonlinear, concentration-dependent pharmacokinetic profile, and has a narrow therapeutic range...

journal_title：Therapeutic drug monitoring

authors： Aliwarga T,Cloyd JC,Goel V,Brundage RC,Marino SE,Leppik IE,Remmel RP

更新日期：2011-02-01 00:00:00

abstract：:The CYP2D6*10(*10) allele that causes decreased CYP2D6 activity is present in Asians with a high frequency of approximately 50%. We studied the effects of the *10 allele on the steady-state plasma concentrations of aripiprazole and its active metabolite, dehydroaripiprazole. The subjects were 63 Japanese patients with...

journal_title：Therapeutic drug monitoring

authors： Suzuki T,Mihara K,Nakamura A,Nagai G,Kagawa S,Nemoto K,Ohta I,Arakaki H,Uno T,Kondo T

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:The aim of the study is to characterize the pharmacokinetics and the gastrointestinal side effect profiles of enteric-coated mycophenolate sodium (EC-MPS) in de novo kidney transplant patients of Hispanic ethnicity. MATERIALS AND METHODS:The pharmacokinetic study of EC-MPS was conducted in 11 de novo kidney ...

journal_title：Therapeutic drug monitoring

authors： Shah T,Tellez-Corrales E,Yang JW,Qazi Y,Wang J,Wilson J,Hutchinson I,Min DI

更新日期：2011-02-01 00:00:00

abstract：:Previous studies have categorized duloxetine as a moderate inhibitor of CYP2D6. The aim of the present study was to investigate the potential interactions between duloxetine and the two CYP2D6 substrates risperidone and aripiprazole in psychiatric patients. Serum concentration data from patients treated with risperido...

journal_title：Therapeutic drug monitoring

authors： Hendset M,Molden E,Enoksen TB,Refsum H,Hermann M

更新日期：2010-12-01 00:00:00

abstract：:Tyrosine kinase inhibitors are the standard of care for the treatment of chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. Dasatinib is a second-generation tyrosine kinase inhibitor that has been shown to be efficacious in treatment of patients with chronic myeloid leukemia or ...

journal_title：Therapeutic drug monitoring

authors： Shayani S

更新日期：2010-12-01 00:00:00

abstract：:Sotrastaurin (AEB071) is an investigational immunosuppressant that blocks T-lymphocyte activation through protein kinase C inhibition. It is currently in Phase II of clinical development for the prevention of acute rejection after solid organ transplantation. In renal transplant clinical trials, sotrastaurin has been ...

journal_title：Therapeutic drug monitoring

authors： Kovarik JM,Slade A

更新日期：2010-10-01 00:00:00

abstract：:Monitoring of serum voriconazole concentrations has been proposed to optimize therapeutic effect and minimize toxicity. However, little is known about the clinical use of voriconazole therapeutic drug monitoring (TDM) by treating physicians. Four hundred seventy-eight episodes corresponding with 161 adult patients (me...

journal_title：Therapeutic drug monitoring

authors： Miyakis S,van Hal SJ,Solvag CJ,Ray J,Marriott D

更新日期：2010-10-01 00:00:00

abstract：UNLABELLED:Oral fluid is an attractive alternative matrix for drug testing with a noninvasive and directly observed collection, but there are few controlled cocaine administration studies to guide interpretation. MATERIALS AND METHODS:While residing on a closed research unit for up to 10 weeks under constant medical s...

journal_title：Therapeutic drug monitoring

authors： Scheidweiler KB,Spargo EA,Kelly TL,Cone EJ,Barnes AJ,Huestis MA

更新日期：2010-10-01 00:00:00

abstract：:A high-performance liquid chromatographic method for the determination of linezolid in human plasma was developed and validated. After precipitation of plasma proteins with perchloric acid, the protein-free supernatant was separated by isocratic reverse-phase chromatography on a X Bridge C18 column. The mobile phase c...

journal_title：Therapeutic drug monitoring

authors： Cattaneo D,Baldelli S,Conti F,Cozzi V,Clementi E

更新日期：2010-08-01 00:00:00

abstract：INTRODUCTION:Enoxaparin is an anticoagulant used in the treatment of thromboembolic diseases. It is a hydrophilic molecule that is, predominantly, eliminated renally with few data to support dosing for subjects with renal impairment and/or obesity. A recently conducted randomized controlled clinical trial compared indi...

journal_title：Therapeutic drug monitoring

authors： Barras MA,Duffull SB,Atherton JJ,Green B

更新日期：2010-08-01 00:00:00

abstract：:Iron overload resulting from transfusion dependency in some patients with chronic anaemia can be prevented by chelation. Deferasirox is an oral alternative to the well studied but inconvenient deferroxamine therapy. The pharmacokinetic parameters of this new drug suggest potential interindividual variability and patie...

journal_title：Therapeutic drug monitoring

authors： Chauzit E,Bouchet S,Micheau M,Mahon FX,Moore N,Titier K,Molimard M

更新日期：2010-08-01 00:00:00

abstract：:The role of drug assays for screening, diagnosis, and guiding treatment decisions in overdose patients remains unclear. The use of drug concentration data in clinical toxicology research is more problematic, with studies using drug concentrations to simply confirm ingestion in observational studies or others report dr...

journal_title：Therapeutic drug monitoring

authors： Isbister GK

更新日期：2010-06-01 00:00:00

abstract：:5-Methoxy-N,N-dialkyltryptamines are tryptamine derivatives that possess strong hallucinogenic effects. Because of their escalating popularity and potent physiological effects, an increasing number of acute poisoning cases have been reported in various countries. For their metabolism in humans, only a few studies have...

journal_title：Therapeutic drug monitoring

authors： Katagi M,Kamata T,Zaitsu K,Shima N,Kamata H,Nakanishi K,Nishioka H,Miki A,Tsuchihashi H

更新日期：2010-06-01 00:00:00

abstract：:The objective of this study was to evaluate the analytical performance of the Abbott ARCHITECT Cyclosporine (CsA) immunoassay in 7 clinical laboratories in comparison to liquid chromatography/tandem mass spectrometry (LC/MS/MS), Abbott TDx, Cobas Integra 800, and the Dade Dimension Xpand immunoassay. The ARCHITECT ass...

journal_title：Therapeutic drug monitoring

authors： Wallemacq P,Maine GT,Berg K,Rosiere T,Marquet P,Aimo G,Mengozzi G,Young J,Wonigeit K,Kretschmer R,Wermuth B,Schmid RW

更新日期：2010-04-01 00:00:00

abstract：:To evaluate the reliability and practical use of saliva for therapeutic drug monitoring of the antifungal agent voriconazole in immunocompromised patients, a paired-sample study was conducted. Plasma and saliva trough levels were measured in seven children and nine adults who required treatment for the prevention or t...

journal_title：Therapeutic drug monitoring

authors： Michael C,Bierbach U,Frenzel K,Lange T,Basara N,Niederwieser D,Mauz-Körholz C,Preiss R

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The once-daily formulation of tacrolimus has been reported to exhibit the same efficacy and safety profile as compared with the immediate-release form administered twice daily. However, as a result of differences in their pharmacokinetic (PK) profile, the PK models or Bayesian estimators (MAP-BE) previously ...

journal_title：Therapeutic drug monitoring

authors： Saint-Marcoux F,Debord J,Undre N,Rousseau A,Marquet P

更新日期：2010-04-01 00:00:00

abstract：:The immunosuppressant mycophenolic acid (MPA) used for solid organ transplantation is predominantly metabolized to a pharmacologically inactive phenolic glucuronide (MPAG) and, to a lesser extent, to the pharmacologically active acyl glucuronide (AcMPAG). The recently introduced CEDIA Mycophenolic Acid Assay from Micr...

journal_title：Therapeutic drug monitoring

authors： Shipkova M,Schütz E,Besenthal I,Fraunberger P,Wieland E

更新日期：2010-02-01 00:00:00

abstract：:Specific chromatographic methods for the measurement of cyclosporin A, tacrolimus, sirolimus, and everolimus blood levels in patients with organ transplants are time consuming when large numbers of samples must be processed. The authors developed a robust and fast (1 minute) online solid-phase extraction liquid chroma...

journal_title：Therapeutic drug monitoring

authors： Meinitzer A,Gartner G,Pilz S,Stettin M

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Raltegravir is the first human immunodeficiency virus-1 (HIV-1) integrase inhibitor used in treatment-experienced patients who have evidence of viral replication and HIV-1 strains resistance to multiple antiretroviral regimens. Etravirine is a novel NNRTI, active against HIV-1 strains harboring multiple NNRT...

journal_title：Therapeutic drug monitoring

authors： Quaranta S,Woloch C,Paccou A,Giocanti M,Solas C,Lacarelle B

更新日期：2009-12-01 00:00:00

abstract：:This study was undertaken to model the relationship between clonazepam plasma concentrations and a central nervous system adverse effect (impairment of the psychomotor performance) following the oral administration of immediate-release tablets of clonazepam in healthy volunteers. Such a (P)pharmacokinetic/(P)pharmacod...

journal_title：Therapeutic drug monitoring

authors： dos Santos FM,Gonçalves JC,Caminha R,da Silveira GE,Neves CS,Gram KR,Ferreira CT,Jacqmin P,Noël F

更新日期：2009-10-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is increasingly used for the treatment of autoimmune diseases (AID). In renal transplant recipients, it has been demonstrated that adjustment of the MMF dose according to the area under the plasma concentration versus time curve (AUC) of mycophenolic acid (MPA), the active moiety of MMF, im...

journal_title：Therapeutic drug monitoring

authors： de Winter BC,Neumann I,van Hest RM,van Gelder T,Mathot RA

更新日期：2009-06-01 00:00:00

abstract：:Oral posaconazole (PSZ), an azole antifungal drug, was recently introduced for the treatment of invasive fungal infections. The prescription of PSZ together with the immunosuppressant tacrolimus (TRL) was evaluated in 14 lung transplant patients with cystic fibrosis. PSZ inhibited CYP3A4 TRL metabolism, resulting in a...

journal_title：Therapeutic drug monitoring

authors： Berge M,Chevalier P,Benammar M,Guillemain R,Amrein C,Lefeuvre S,Boussaud V,Billaud EM

更新日期：2009-06-01 00:00:00

abstract：:A serious challenge in diagnosing fetal alcohol spectrum disorder (FASD) is the need to document alcohol use during pregnancy. Maternal/paternal alcohol abuse affects the likelihood of fetal alcohol exposure, and hence the occurrence of FASD. The objective of the current study was to document the use of the fatty acid...

journal_title：Therapeutic drug monitoring

authors： Kulaga V,Pragst F,Fulga N,Koren G

更新日期：2009-04-01 00:00:00

abstract：:Gabapentin is used in analgesic treatment of neuropathic pain, and large interindividual variation has been observed in the pharmacokinetics (PK) of the drug. The aim of this study was to develop a population PK model for gabapentin appropriate for monitoring patients with neuropathic pain and for individualizing thei...

journal_title：Therapeutic drug monitoring

authors： Carlsson KC,van de Schootbrugge M,Eriksen HO,Moberg ER,Karlsson MO,Hoem NO

更新日期：2009-02-01 00:00:00

abstract：:Urinary excretion of lipocalin-type prostaglandin D synthase (L-PGDS) has been suggested to be a useful biomarker of early diabetic nephropathy. We studied whether L-PGDS is also a marker of gentamicin (GM)-induced renal damage in the "creatinine-blind" range. A prospective study was conducted in 6 patients who were g...

journal_title：Therapeutic drug monitoring

authors： Nakayama H,Echizen H,Gomi T,Shibuya Y,Nakamura Y,Nakano K,Arashi H,Itai T,Ohnishi S,Tanaka M,Orii T

更新日期：2009-02-01 00:00:00